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Table of Contents
What is Microbiota?
- Microbiota are the large number of microorganisms including a large number of bacteria, viruses, fungi, and protozoa, that are present in our body.
- Microbiota, is an assemble of commensal, symbiotic and pathogenic micro-organisms that resides in a particular habitat or environment.
- Human body consists of trillions of microbes, or bacteria which are useful as well as harmful.
- Every human being consist anywhere between 10 trillion and 100 trillion microbial cells in symbiotic relationship and has co-evolved with host over thousands of years to form an intricate and mutually beneficial relationship
What is Gut Microbiota?
- Human body consists of complex and dynamic groups of bacteria, viruses, fungi and other single celled animals that live in the body especially in gastro-intestinal tract
- The collection of these bacteria, viruses and fungi colonizing the GI tract is termed as gut microbiota.
- It exists symbiotically within the human digestive system and helps support energy harvesting, digestion, and immune defense.
Key Facts
- Microbiota is made up of trillions of cells, including bacteria, fungi and viruses
- The biggest population of microbiota resides in the gut. Other popular habitat include the skin, throat, mouth and genitals
- The microbial cells and their genetic materials, the microbiome, live with humans from births which relationship is vital to normal health
- The microorganisms living inside the gastrointestinal tract amount to around 4 pounds of biomass where every individual has a unique mix of species
- Microbiota is important for nutrition, immunity and effects on the brain and behavior. It is implicated in a number of diseases that cause a disturbance in the normal balance of microbes
Functions
Microbiota interplay serving to play many and major functions in our body. These include:
- Regulation of immune system
- Digestion of food
- Production of vitamins like B12 and K
- Metabolization of xenobiotic materials
- Prevention and protection against pathogenic infections
- Strengthening biochemical barriers of the gut and the intestine
- Digestion of dietary carcinogens
- Provides innate and adaptive immunity
- Provides colonization resistance
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Factors Affecting Microbiota Present In The Body
- Human micro-biota is not a stable organ which is affected by lot of factors
- Aging also shows a significant change in the composition of the micro-biota
- In addition to age, diet and lifestyle, host genetics, environmental contact, infection, pharmaceuticals, hygiene conditions, relationship between microbiota and immune system, even geography cause variation
- Pregnancy
- Psychological stress/anxiety
- Tobacco use
- Alcohol consumption also affects the micro-biota composition
- Mode of delivery (Normal or caesarean)
- Diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based)
- Healthy foods (contributes to healthy microbiota)
- Use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community
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Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162693/#:~:text=The%20microbiota%20affects%20many%20vital,materials%2C%20and%20many%20other%20tasks.
Benefits
- Micro-biota affects the body from birth and throughout life by controlling the digestion of food, immune system, central nervous system and other bodily processes
- Some microbiota begins to grow in intestines of babies helping to digest breast milk
- It is essential for the development of the intestinal mucosa and immune system of the host
- It also controls the immune system by communicating with the immune cells and control how the body response to infection
- It has potential to extract increased energy from food and increase nutrient harvest
- It provides humans with unique and specific enzymes and biochemical pathways
- It provides a physical barrier, protecting its host against foreign pathogens through competitive exclusion and the production of antimicrobial substances
Negative Effects/Impacts of Microbiota
- Dysbiosis/Imbalance of microbiota causes the infection
- Disturbance of the microbiota is also associated with the progression of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and other diseases
- Disturbance in the microbiota can contribute to chronic kidney disease
- It can also affect negatively by increasing the weights when there is imbalance among the micro-biota
- Metabolic syndromes like diabetes and obesity occurs when there is imbalance in the micro-biota
- Gastro intestinal disorders are must to occur if any changes happens in the gut micro-biota
- Chances of colon cancer development is also increased due to negative microbiota
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Effects of Poor Microbiota Diversity In Human Health
Lack of diversity leads to many diseases. Some of the common diseases are:
- Autoimmune diseases such as diabetes type I
- Rheumatism
- Muscular dystrophy
- Problems in blood coagulation due to lack of vitamin K,
- and disturbances in the transfer of nerve cells due to lack of vitamin B12,
- Additionally, it is also involved in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer’s disease.
- Poor microbiota diversity also have negative effects on nutrition status of a child which ultimately leads undernutrition among children.
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How to Improve the Health of Microbiota
- Eating proper diet of vegetables, legumes, beans, and fruits
- Exclusive breastfeeding of babies until 6 months
- Increase in the take of probiotics
- Eating more of a plant based diet
- Eating fermented foods like yogurt
- Intake of fiber rich foods and avoiding sugars and sweeteners
- Avoiding unnecessary intake of antibiotics
- Maintaining proper physical activity and regular exercise
- Getting proper sleep and becoming stress free
- Avoiding smoking and alcohol consumption
References and For More Information
https://www.scirp.org/journal/paperinformation.aspx?paperid=96630
https://link.springer.com/article/10.1007/s00203-020-01931-x
https://amb-express.springeropen.com/articles/10.1186/s13568-020-01066-8
https://www.sciencedirect.com/science/article/pii/S2095809917301492#f0005
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566439/#__sec7title
https://www.healthline.com/nutrition/why-bifidobacteria-are-good
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962619/
https://www.nature.com/articles/nri3430
https://kids.frontiersin.org/articles/10.3389/frym.2017.00035
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/
https://www.medicalnewstoday.com/articles/307998#summary