Table of Contents
What is Microbiota?
- Microbiota are the large number of microorganisms including a large number of bacteria, viruses, fungi, and protozoa, that are present in our body.
- Microbiota, is an assemble of commensal, symbiotic and pathogenic micro-organisms that resides in a particular habitat or environment.
- Human body consists of trillions of microbes, or bacteria which are useful as well as harmful.
- Every human being consist anywhere between 10 trillion and 100 trillion microbial cells in symbiotic relationship and has co-evolved with host over thousands of years to form an intricate and mutually beneficial relationship
What is Gut Microbiota?
- Human body consists of complex and dynamic groups of bacteria, viruses, fungi and other single celled animals that live in the body especially in gastro-intestinal tract
- The collection of these bacteria, viruses and fungi colonizing the GI tract is termed as gut microbiota.
- It exists symbiotically within the human digestive system and helps support energy harvesting, digestion, and immune defense.
Key Facts
- Microbiota is made up of trillions of cells, including bacteria, fungi and viruses
- The biggest population of microbiota resides in the gut. Other popular habitat include the skin, throat, mouth and genitals
- The microbial cells and their genetic materials, the microbiome, live with humans from births which relationship is vital to normal health
- The microorganisms living inside the gastrointestinal tract amount to around 4 pounds of biomass where every individual has a unique mix of species
- Microbiota is important for nutrition, immunity and effects on the brain and behavior. It is implicated in a number of diseases that cause a disturbance in the normal balance of microbes
Functions
Microbiota interplay serving to play many and major functions in our body. These include:
- Regulation of immune system
- Digestion of food
- Production of vitamins like B12 and K
- Metabolization of xenobiotic materials
- Prevention and protection against pathogenic infections
- Strengthening biochemical barriers of the gut and the intestine
- Digestion of dietary carcinogens
- Provides innate and adaptive immunity
- Provides colonization resistance
Factors Affecting Microbiota Present In The Body
- Human micro-biota is not a stable organ which is affected by lot of factors
- Aging also shows a significant change in the composition of the micro-biota
- In addition to age, diet and lifestyle, host genetics, environmental contact, infection, pharmaceuticals, hygiene conditions, relationship between microbiota and immune system, even geography cause variation
- Pregnancy
- Psychological stress/anxiety
- Tobacco use
- Alcohol consumption also affects the micro-biota composition
- Mode of delivery (Normal or caesarean)
- Diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based)
- Healthy foods (contributes to healthy microbiota)
- Use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community
Benefits
- Micro-biota affects the body from birth and throughout life by controlling the digestion of food, immune system, central nervous system and other bodily processes
- Some microbiota begins to grow in intestines of babies helping to digest breast milk
- It is essential for the development of the intestinal mucosa and immune system of the host
- It also controls the immune system by communicating with the immune cells and control how the body response to infection
- It has potential to extract increased energy from food and increase nutrient harvest
- It provides humans with unique and specific enzymes and biochemical pathways
- It provides a physical barrier, protecting its host against foreign pathogens through competitive exclusion and the production of antimicrobial substances
Negative Effects/Impacts of Microbiota
- Dysbiosis/Imbalance of microbiota causes the infection
- Disturbance of the microbiota is also associated with the progression of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and other diseases
- Disturbance in the microbiota can contribute to chronic kidney disease
- It can also affect negatively by increasing the weights when there is imbalance among the micro-biota
- Metabolic syndromes like diabetes and obesity occurs when there is imbalance in the micro-biota
- Gastro intestinal disorders are must to occur if any changes happens in the gut micro-biota
- Chances of colon cancer development is also increased due to negative microbiota
Effects of Poor Microbiota Diversity In Human Health
Lack of diversity leads to many diseases. Some of the common diseases are:
- Autoimmune diseases such as diabetes type I
- Rheumatism
- Muscular dystrophy
- Problems in blood coagulation due to lack of vitamin K,
- and disturbances in the transfer of nerve cells due to lack of vitamin B12,
- Additionally, it is also involved in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer’s disease.
- Poor microbiota diversity also have negative effects on nutrition status of a child which ultimately leads undernutrition among children.
How to Improve the Health of Microbiota
- Eating proper diet of vegetables, legumes, beans, and fruits
- Exclusive breastfeeding of babies until 6 months
- Increase in the take of probiotics
- Eating more of a plant based diet
- Eating fermented foods like yogurt
- Intake of fiber rich foods and avoiding sugars and sweeteners
- Avoiding unnecessary intake of antibiotics
- Maintaining proper physical activity and regular exercise
- Getting proper sleep and becoming stress free
- Avoiding smoking and alcohol consumption
References and For More Information
https://www.scirp.org/journal/paperinformation.aspx?paperid=96630
https://link.springer.com/article/10.1007/s00203-020-01931-x
https://amb-express.springeropen.com/articles/10.1186/s13568-020-01066-8
https://www.sciencedirect.com/science/article/pii/S2095809917301492#f0005
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566439/#__sec7title
https://www.healthline.com/nutrition/why-bifidobacteria-are-good
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962619/
https://www.nature.com/articles/nri3430
https://kids.frontiersin.org/articles/10.3389/frym.2017.00035
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/
https://www.medicalnewstoday.com/articles/307998#summary