Microbiota: Functions, Advantages, Factors & Improvement Techniques

What is Microbiota?

  • Microbiota are the large number of microorganisms including a large number of bacteria, viruses, fungi, and protozoa, that are present in our body.
  • Microbiota, is an assemble of commensal, symbiotic and pathogenic micro-organisms that resides in a particular habitat or environment.
  • Human body consists of trillions of microbes, or bacteria which are useful as well as harmful.
  • Every human being consist anywhere between 10 trillion and 100 trillion microbial cells in symbiotic relationship and has co-evolved with host over thousands of years to form an intricate and mutually beneficial relationship

What is Gut Microbiota?

  • Human body consists of complex and dynamic groups of bacteria, viruses, fungi and other single celled animals that live in the body especially in gastro-intestinal tract
  • The collection of these bacteria, viruses and fungi colonizing the GI tract is termed as gut microbiota.
  • It exists symbiotically within the human digestive system and helps support energy harvesting, digestion, and immune defense.

Key Facts

  • Microbiota is made up of trillions of cells, including bacteria, fungi and viruses
  • The biggest population of microbiota resides in the gut. Other popular habitat include the skin, throat, mouth and genitals
  • The microbial cells and their genetic materials, the microbiome, live with humans from births which relationship is vital to normal health
  • The microorganisms living inside the gastrointestinal tract amount to around 4 pounds of biomass where every individual has a unique mix of species
  • Microbiota is important for nutrition, immunity and effects on the brain and behavior. It is implicated in a number of diseases that cause a disturbance in the normal balance of microbes

Functions

Microbiota interplay serving to play many and major functions in our body. These include:

  • Regulation of immune system
  • Digestion of food
  • Production of vitamins like B12 and K
  • Metabolization of xenobiotic materials
  • Prevention and protection against pathogenic infections
  • Strengthening biochemical barriers of the gut and the intestine
  • Digestion of dietary carcinogens
  • Provides innate and adaptive immunity
  • Provides colonization resistance
Figure: Function of Microbiota in Human Body

Factors Affecting Microbiota Present In The Body

  • Human micro-biota is not a stable organ which is affected by lot of factors
  • Aging also shows a significant change in the composition of the micro-biota
  • In addition to age, diet and lifestyle, host genetics, environmental contact, infection, pharmaceuticals, hygiene conditions, relationship between microbiota and immune system, even geography cause variation
  • Pregnancy
  • Psychological stress/anxiety
  • Tobacco use
  • Alcohol consumption also affects the micro-biota composition
  • Mode of delivery (Normal or caesarean)
  • Diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based)
  • Healthy foods (contributes to healthy microbiota)
  • Use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community

 

Figure: Factors influencing the pediatric microbiota up to 3 years of age
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162693/#:~:text=The%20microbiota%20affects%20many%20vital,materials%2C%20and%20many%20other%20tasks.

Benefits

  • Micro-biota affects the body from birth and throughout life by controlling the digestion of food, immune system, central nervous system and other bodily processes
  • Some microbiota begins to grow in intestines of babies helping to digest breast milk
  • It is essential for the development of the intestinal mucosa and immune system of the host
  • It also controls the immune system by communicating with the immune cells and control how the body response to infection
  • It has potential to extract increased energy from food and increase nutrient harvest
  • It provides humans with unique and specific enzymes and biochemical pathways
  • It provides a physical barrier, protecting its host against foreign pathogens through competitive exclusion and the production of antimicrobial substances

Negative Effects/Impacts of Microbiota

  • Dysbiosis/Imbalance of microbiota causes the infection
  • Disturbance of the microbiota is also associated with the progression of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and other diseases
  • Disturbance in the microbiota can contribute to chronic kidney disease
  • It can also affect negatively by increasing the weights when there is imbalance among the micro-biota
  • Metabolic syndromes like diabetes and obesity occurs when there is imbalance in the micro-biota
  • Gastro intestinal disorders are must to occur if any changes happens in the gut micro-biota
  • Chances of colon cancer development is also increased due to negative microbiota
Source: https://www.sciencedirect.com/science/article/pii/S2095809917301492#f0005

Effects of Poor Microbiota Diversity In Human Health

Lack of diversity leads to many diseases. Some of the common diseases are:

  • Autoimmune diseases such as diabetes type I
  • Rheumatism
  • Muscular dystrophy
  • Problems in blood coagulation due to lack of vitamin K,
  • and disturbances in the transfer of nerve cells due to lack of vitamin B12,
  • Additionally, it is also involved in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer’s disease.
  • Poor microbiota diversity also have negative effects on nutrition status of a child which ultimately leads  undernutrition among children.
Figure: Gut microbiota and Undernutrition Source: https://www.science.org/doi/abs/10.1126/science.aad9359

How to Improve the Health of Microbiota

  • Eating proper diet of vegetables, legumes, beans, and fruits
  • Exclusive breastfeeding of babies until 6 months
  • Increase in the take of probiotics
  • Eating more of a plant based diet
  • Eating fermented foods like yogurt
  • Intake of fiber rich foods and avoiding sugars and sweeteners
  • Avoiding unnecessary intake of antibiotics
  • Maintaining proper physical activity and regular exercise
  • Getting proper sleep and becoming stress free
  • Avoiding smoking and alcohol consumption

References and For More Information

https://www.scirp.org/journal/paperinformation.aspx?paperid=96630

https://link.springer.com/article/10.1007/s00203-020-01931-x

https://amb-express.springeropen.com/articles/10.1186/s13568-020-01066-8

https://www.sciencedirect.com/science/article/pii/S2095809917301492#f0005

https://www.researchgate.net/figure/Effects-of-the-gut-microbiome-on-host-health-Some-of-the-many-known-effects-of-the-gut_fig1_340544296

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566439/#__sec7title

https://www.healthline.com/nutrition/why-bifidobacteria-are-good

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962619/

https://www.google.com/url?q=https://www.thegutmicrobiome.com/factors-that-influence-gut-microbiota/&usg=AOvVaw3tbGK1cecob87e5uYYH4cD

https://www.google.com/url?q=https://www.medicalnewstoday.com/articles/307998&usg=AOvVaw26y76kmgBimlFhZrBFwqtk

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162693/#:~:text=The%20microbiota%20affects%20many%20vital,materials%2C%20and%20many%20other%20tasks.

https://www.nature.com/articles/nri3430

https://kids.frontiersin.org/articles/10.3389/frym.2017.00035

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/

https://www.medicalnewstoday.com/articles/307998#summary

About Rojina Shrestha 81 Articles
Ms. Rojina Shrestha is a public health professional. She holds Bachelor Degree in Public Health (BPH) from a reputed University. Ms. Shrestha is an enthusiast who loves to write public health related articles and is also engaged in carrying out various public health researches.